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Fountain of Youth: Immortality Achievable by Altering Chromosomes

A long sought-after miracle, scientists now say they have a solution to one of mankindā€™s most ancient pursuits: eternal life.

Fountain of Youth: Immortality Achievable by Altering Chromosomes

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A long sought-after miracle, scientists now say they have a solution to one of mankindā€™s most ancient pursuits: eternal life.

In the 16th century, Ponce de Leon traveled toĀ Florida inĀ search ofĀ the Fountain ofĀ Youth. So the legend goes, atĀ least. Dracula, the vampire creation ofĀ Bram Stoker, achieves immortality byĀ feeding offĀ the living. Even the Indiana Jones series employs one ofĀ its several Nazi face-melting scenes afterĀ the villain drinks fromĀ a phony Holy Grail.

Though clearly popular inĀ fiction and lore, immortality has been elusive. But a group ofĀ scientists now think they have the key, and it may lie atĀ the most base level ofĀ aging: our chromosomes.

All chromosomes are protected byĀ thin, protective caps known asĀ telomeres. Located onĀ each end ofĀ a chromosome, these telomeres defend againstĀ deterioration asĀ cells grow.

Telomeres are located at the ends of chromosomes.
Telomeres are located at the ends of chromosomes.

Eventually, however, telomeres become worn down, or shortened, and this is thought toĀ be a major culprit inĀ the aging process. While the telomeres ofĀ the young tend toĀ be betweenĀ 8,000 and 10,000 nucleotides long, this number gradually declines asĀ we age.

This new process, discovered byĀ Helen Blau and her team atĀ Stanford University, would allow scientists toĀ strengthen deteriorating telomeres, thereby making the treated cells ā€œyounger.ā€

ā€œThis new approach paves the way towardĀ preventing or treating diseases ofĀ aging,ā€ one ofĀ the researches said. ā€˜There are also highly debilitating genetic diseases associated withĀ telomere shortening that could benefit fromĀ such a potential treatment.ā€

Specifically, scientists plan toĀ apply the procedure toĀ patients suffering fromĀ genetic diseases likeĀ muscular dystrophy, asĀ well asĀ diabetes and heart disease.

ā€œNow we have found a way toĀ lengthen human telomeres byĀ as much 1,000 nucleotides, turning back the internal clock inĀ these cells byĀ the equivalent ofĀ many years ofĀ human life,ā€ said Brau. ā€œThis greatly increases the number ofĀ cells available forĀ studies such asĀ drug testing or disease modeling.

The development may sound familiar. Over the last few years, Shin Kubota, a Japanese scientist, has been culturing a rare breed ofĀ invertebrates known asĀ Turritopsis dohrnii, though more commonly known as ā€œimmortal jellyfish.ā€

The jellyfish has a strange ability toĀ reverse its own aging process, growing younger untilĀ it reaches its earliest form ofĀ development, and then begins toĀ grow again.

With the fight againstĀ aging opening onĀ multiple fronts, it may only be a matter ofĀ time beforeĀ weā€™re all living asĀ Dracula. Just withoutĀ all the violence.

Read more: http://sputniknews.com/science/20150204/1017790615.html#ixzz3R5macIeH

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