Deadly bacteria release sparks concern at high-security Louisiana lab for vaccine research on pathogen that escaped –Several countries [aka the US] have studied using the bacteria as a bioweapon. | 2 Mar 2015 |A dangerous, often deadly, type of bacteria that lives in soil and water has been released from a high-security [Biosafety Level 3 (BSL-3)] laboratory at the Tulane National Primate Research Center in Louisiana. Despite weeks of investigation by multiple federal and state agencies, the cause of the release and the extent of the contamination remain unknown, according to interviews and records obtained by USA TODAY. The Tulane incident involves the release, possibly in November or earlier, of a bacterium called Burkholderia pseudomallei…Tulane’s research, which has been halted by federal officials, was part of an effort to develop a vaccine against the bacteria [that was released].
(USA TODAY) – A dangerous, often deadly, type of bacteria that lives in soil and water has been released from a high-security laboratory at the Tulane National Primate Research Center in Louisiana. Officials say there is no risk to the public. Yet despite weeks of investigation by multiple federal and state agencies, the cause of the release and the extent of the contamination remain unknown, according to interviews and records obtained by USA TODAY.
The incident has raised concerns that bacteria from the lab may have contaminated the facility’s grounds and though initial, limited tests didn’t detect it, some officials are pressing behind the scenes for more action, records show. The safety breach at Tulane’s massive lab complex 35 miles north of New Orleans is the latest in a recent series of significant biosafety accidents at some of the most prestigious laboratories in the country where research is performed on bacteria and viruses that are classified as potential bioterror agents.
“The fact that they can’t identify how this release occurred is very concerning,” said Richard Ebright, a biosafety expert from Rutgers University in New Jersey, who testified before Congress last summer in the wake of lab incidents at federal agencies involving anthrax, smallpox and a deadly strain of avian influenza.
The Tulane incident involves the release, possibly in November or earlier, of a bacterium called Burkholderia pseudomallei, which is primarily found in Southeast Asia and northern Australia and is spread to humans and animals through direct contact with contaminated soil and water where it can live and grow. Tulane’s research, which has been halted by federal officials, was part of an effort to develop a vaccine against the bacteria. It was conducted mostly with rodents inside a secure biosafety level 3 laboratory with multiple layers of safety equipment that were supposed to ensure the pathogen couldn’t get out.
Yet at least four monkey-like rhesus macaques — that were never used in the experiments and were kept in large outdoor cages in another part of the 500-acre facility — have been exposed to the bacteria, initial tests have found. Two of the macaques became ill in November; both eventually had to be euthanized. Meanwhile, a federal investigator, who became ill 24 hours after visiting the facility in January as part of the ongoing release investigation, has also tested positive for exposure to the bacteria — though it remains unclear whether her exposure may have occurred during international travel and not at the lab.
“We’re taking this extraordinarily seriously. It’s very disturbing to us,” said Andrew Lackner, director of the Tulane primate center. “Right from the beginning we’ve spent an enormous amount of time trying to figure out how this could have happened.”
Lackner said the investigation so far indicates that the four macaques were exposed to the bacteria while being cared for in the complex’s veterinary hospital and he emphasized that tests of 39 soil and 13 water samples from the center’s grounds have not detected the presence of the bacteria.
“There has never been a public health threat,” Lackner said.
Yet studies reviewed by USA TODAY indicate too few samples were taken to detect what can be an elusive bacterium. The Louisiana Governor’s Office of Homeland Security and Emergency Preparedness, which is leading the joint federal-state response, expressed concerns about “whether the organism has escaped the compound and whether livestock and domestic animals are at risk,” in a Feb. 20 letter from the state to the U.S. Environmental Protection Agency. The state provided a copy to USA TODAY on Friday.
The letter formally asked the EPA for help addressing potential soil contamination where sick macaques were housed, including with testing and assistance “to perform soil remediation in area(s) identified as high-risk as soon as possible to prevent further transmission/transference.”
The primate center is located in Covington, La., near wetlands and a river, across the street from a school and close to a neighborhood.
Officials at state and federal agencies responded to some questions via e-mail but did not grant interviews. The Centers for Disease Control and Prevention, which is leading the investigation of the laboratory breach because the bacterium is classified as a potential bioterror agent, said its investigation is ongoing and that at this time “there is no known public health threat.”
The U.S. Department of Agriculture, which is jointly investigating the lab breach with CDC, said in an e-mail: “USDA is still evaluating if a risk to Louisiana agriculture exists.”
