New study finds organ recipients rejecting transplant after receiving COVID vaccine
INDIANAPOLIS (WISH) — Some transplant recipients are rejecting their new organ and scientists say the coronavirus vaccine may be to blame.
According to a new study published in the Journal of Clinical Medicine, acute corneal allografts are being rejected by immunized patients who’ve undergone the procedure. Researchers say the underlying cause could be tied to a systemic inflammatory response elicited by the shot post-jab.
The study …
Characteristics and Clinical Ocular Manifestations in Patients with Acute Corneal Graft Rejection after Receiving the COVID-19 Vaccine: A Systematic Review
Also found this …
Acute Kidney Allograft Rejection Following Coronavirus mRNA Vaccination: A Case Report
Since the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, worldwide efforts to develop and institute mass vaccination campaigns have proven efficacious in stemming coronavirus disease 2019 (COVID-19)–associated morbidity and mortality. Recipients of solid organ transplants (SOTs) represent a vulnerable population for infection with SARS-CoV-2 and subsequent morbidity and mortality from COVID-19.1 Various studies have estimated mortality rates between 18% and 43% in kidney transplant recipients and higher rates of acute kidney injury and graft failure have been reported.1,2
Development of vaccines against SARS-CoV-2, including multiple mRNA-based vaccines, has largely resulted in preventing and reducing severe COVID-19 disease.3,4 The immunogenicity of these vaccines has been demonstrated in healthy patients. However, the majority of these trials have excluded recipients receiving long-term immunosuppressive therapy including SOT recipients. Two of the leading available vaccines use mRNA-based technology, with variable immunological responses in SOT recipients. Subsequent analyses of the efficacy of COVID-19 vaccination in this population confirmed their safe use, although patients exhibited diminished immunogenic responses, likely owing to baseline immunosuppression. Furthermore, vaccination side effects remain very uncommon, although complications such as myocarditis and Bell’s palsy have been reported to the Centers of Disease Control Vaccine Adverse Events Reporting database.5 Herein, we review a case of severe acute allograft rejection in a kidney transplant recipient temporally related to immunization with the mRNA-1273 SARS-CoV-2 (Moderna) vaccine.
🇯🇵 🇺🇸 Transplant patients rejecting organ after COVID vaccine pic.twitter.com/aoff4XzGZR
— 𝚁𝙰𝙶𝙴 𝙰𝙶𝙰𝙸𝙽𝚂𝚃 𝚃𝙷𝙴 𝚅𝙰𝙲𝙲𝙸𝙽𝙴 (@72powpow) September 14, 2022