New study finds organ recipients rejecting transplant after receiving COVID vaccine
INDIANAPOLIS (WISH) ā Some transplant recipients are rejecting their new organ and scientists say the coronavirus vaccine may be to blame.
According to a newĀ studyĀ published in theĀ Journal of Clinical Medicine, acute corneal allografts are being rejected by immunized patients whoāve undergone the procedure. Researchers say the underlying cause could be tied to a systemic inflammatory response elicited by the shot post-jab.
The study ā¦
Characteristics and Clinical Ocular Manifestations in Patients with Acute Corneal Graft Rejection after Receiving the COVID-19 Vaccine: A Systematic Review
Abstract
This study aimed to determine the characteristics and clinical ocular manifestations of acute corneal graft rejection after coronavirus disease 2019 (COVID-19) vaccination. We conducted an online search of the PubMed and EMBASE databases. Data on recipientsā characteristics, corneal transplantation types, interval between vaccination and allograft rejection, clinical manifestations, and graft rejection medication were extracted. Thirteen articles on 21 patients (23 eyes) with acute corneal graft rejection after COVID-19 vaccination, published between April and December 2021, were included. The median (interquartile range) age at the onset of rejection was 68 (27ā83) years. Types of transplantation included penetrating keratoplasty (12 eyes), Descemet membrane endothelial keratoplasty (six eyes), Descemet stripping automated endothelial keratoplasty (four eyes), and living-related conjunctival-limbal allograft (one eye). The interval between vaccination and rejection ranged from 1 day to 6 weeks. Corneal edema was the leading clinical manifestation (20 eyes), followed by keratic precipitates (14 eyes) and conjunctival or ciliary injection (14 eyes). Medications included frequently applied topical corticosteroids (12 eyes), followed by a combination of topical and oral corticosteroids (four eyes). In addition, the clinical characteristics of corneal allograft rejection after COVID-19 vaccination were identified. Corneal transplant recipients may require further vaccination, necessitating appropriate management and treatment.Ā View Full-Text
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Acute Kidney Allograft Rejection Following Coronavirus mRNA Vaccination: A Case Report
INTRODUCTION
Since the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, worldwide efforts to develop and institute mass vaccination campaigns have proven efficacious in stemming coronavirus disease 2019 (COVID-19)āassociated morbidity and mortality. Recipients of solid organ transplants (SOTs) represent a vulnerable population for infection with SARS-CoV-2 and subsequent morbidity and mortality from COVID-19.1 Various studies have estimated mortality rates between 18% and 43% in kidney transplant recipients and higher rates of acute kidney injury and graft failure have been reported.1,2Development of vaccines against SARS-CoV-2, including multiple mRNA-based vaccines, has largely resulted in preventing and reducing severe COVID-19 disease.3,4 The immunogenicity of these vaccines has been demonstrated in healthy patients. However, the majority of these trials have excluded recipients receiving long-term immunosuppressive therapy including SOT recipients. Two of the leading available vaccines use mRNA-based technology, with variable immunological responses in SOT recipients. Subsequent analyses of the efficacy of COVID-19 vaccination in this population confirmed their safe use, although patients exhibited diminished immunogenic responses, likely owing to baseline immunosuppression. Furthermore, vaccination side effects remain very uncommon, although complications such as myocarditis and Bellās palsy have been reported to the Centers of Disease Control Vaccine Adverse Events Reporting database.5 Herein, we review a case of severe acute allograft rejection in a kidney transplant recipient temporally related to immunization with the mRNA-1273 SARS-CoV-2 (Moderna) vaccine.
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